Adrienne and her cat Langston are planning a quiet weekend in a psychiatric clinic to recover from their arachnophobia (fear of spiders). Itsy is secretly traveling with them in their luggage. At the clinic, Itsy meets the beetle Julius who has a very difficult relationship with the cleaning personal …. Together, Julius and Itsy cause a lot of trouble in the peaceful sanctuary. Finally, two crazy patients - one dressed as doctor and one as a nurse, want to interrupt a lobotomy which is to be performed on Adrienne and Langston to heal them from their phobia. Itsy saves them at the very last moment

Adrienne is invited to a cooking show on television. Itsy is curious and comes along. In the studio, the naughty little spider causes great confusion. The live show turns out to be a disaster, but the audience has a lot of fun ...

Itsy's little friend Leslie wants to study karate. She registers to take lessons at Adrienne's studio. Itsy decides to join her. On the day of the first lesson, a famous karate master is expected. When the exterminator passes the building he discovers the spider on his spider radar. When he storms into the studio, Adrienne mistakes him for the karate master. The exterminator starts his fight against Itsy - and leaves the studio in ruins while Itsy enjoys himself tremendously ....

Leslie goes camping in the mountains with her Girl scout troop. Itsy travels in her luggage. Adrienne, the lazy Girl Scout leader orders the girls to work while she and her cat sleep in the sun. When Adrienne discovers Itsy she informs the ranger who tries to get rid of the spider, he does so in vain. Adrienne goes canoeing with Langston - unfortunately, she does not know that there is a dangerous water fall on the river. Itsy and the girls save them at the very last moment and get a medal of honor for their bravery.

Adrienne has hired a gardener, to beautify her garden for an important meeting with the "Committee against dirty things". But the gardener is old and short sighted, he love flowers, so he won't cut them ... Adrienne is furious and wants to fire him. She calls the exterminator to get rid of bugs and Itsy in her garden. The consequences are terrible - for Adrienne. The committee members are shocked - Adrienne suffers a nervous breakdown and Itsy can't stop laughing ...

The cat, Langston has caught Itsy and Adrienne wants to sell him in her pet shop. Itsy is put in a glass bowl in Adrienne's shop in a huge shopping mall. Leslie finds her friend and secretly frees Itsy from his prison. When Adrienne finds out she screams for help: "Thieves". The head of security tries to capture Itsy, but accidentally pushes the wrong button and sets all of the animals in the shop free ... The hunt is on in the malla!

Adrienne takes Langston and Leslie on a cruise. Leslie would never go on such a long trip without Itsy. While Adrienne tries to seduce the captain, Langston falls into the sea and tries to get back on board ... Meanwhile, Itsy has made a new enemy: the chef de cuisine who feels humiliated the spider sits on his salad and he tries to kill with a huge gun. The ship sinks, but Itsy and Leslie are save on a boat.

Itsy and Leslie are watching TV. They are bored. Suddenly they hear that a circus is marching through town. The fast director Adrienne gave a free ticket to Leslie which turns out to be invalid. Leslie and Itsy sneak into the circus and enjoy the show until Adrienne discovers them and starts to chase them away. Itsy has to fight the body builder but becomes the star of the show ...

Leslie, George and Itsy go skiing. Because George does not know how to ski, he has to take ski lessons. Adrienne is his teacher. She treats him very badly, and when she discovers Itsy she calls the exterminator. The exterminator hunts for the spider. Leslie has to save George who speeds down a steep hill ... Itsy gets rid of his pursuer, and George is the surprise winner of the local ski race.

Itsy and Leslie visit the Paranoid Studios in Hollywood, where Leslie takes part in a talent competition. But the baby movie mogul decides that Itsy is the up and coming new star. Unfortunately, their very first film turns out to be a flop - it seems that Itsy has ruined Hollywood.

Itsy and Leslie go shopping in the supermarket. Itsy is especially fascinated by the huge freezer filled with innumerable types of ice cream. Too bad, Adrienne also wants to buy some ice cream. When she discovers Itsy, she starts screaming. The exterminator has to take her home. Afterward, Itsy and Leslie returned to their garden where they tell each other stories. Itsy tells Leslie the fabulous story about a spider family who was disturbed during a picnic by Miss Muffet, who simply hated spiders ...

Leslie and George are taking ballet lessons. The director Adrienne is convinced that both have no talent at all. It's no wonder, Itry tries to help them. The day of the great performance has come. The Nutcracker is to be shown. Itsy's crazy ideas turn the boring performance into a breathtaking show - great fun for the whole audience.

Itsy and Leslie are reading a book about spiders. The most fascinating story is about the "Black Widow". They are shocked by the fact that this spider kills and eats her husband ... When Itsy goes for a walk in the forest he suddenly hears a beautiful singing. Itsy follows the sound and enters a cave: it is the home of the "Black Widow" who tries to seduce and marry him ... But Leslie shows up in time to save her friend from the hungry widow ..