On the mighty Mississippi River, a tug boat captain, a raft riding pool shark, and a pair of frog catchers each set out to make their fortunes. And when they aren't struggling with the speeding currents and high waters of the river, they're dealing with the other obstacles that come at them fast and furious... A pool hustle goes south and turns dangerous, a crew runs into trouble when an old ship they're bringing home too tall to fit under a river bridge, and the fishermen building their business come across a territorial local standing in their way. But these men face the challenges head on, and brace themselves for a wild ride ahead.

The Mississippi River curves and bends from Minnesota to Louisiana... and so do the fortunes of the people out on the river. Gary and Eddie move up into the catfishing business, only to find that it's far more cut throat than they expected and they'll have to be creative to survive. While the Tubbs tug boat crew rush to save a sinking boat, Matt's rushes to save his own hide after a pool hustle gets out of hand. And an old treasure hunter with a new first mate at his side starts his journey. They all learn quickly that you never know what the river will throw your way.

Pool hustler Matt needs money to send home so he heads back out on the river in Wisconsin. Gary and Eddie are short on their Zydeco order due to poacher so they head out into big water. Ike and Jack tangle with a tree on the paddle boat.

Life on the Mississippi River is a constant battle... and you have to be smart enough to make the right decisions when it counts most. Bryant Tubbs finds himself in the crosshairs of a dangerous storm while working on a big job. Despite successes along the way, Ike and Jack's personal relationship reaches its boiling point and may derail their entire journey. And while a pool hustler in Iowa finds a new partner, Gary and Eddie get locked in a standoff with an old enemy. The stakes have become life and death and each of these river men will have to decide if it's worth it to keep going.

With their journey on the Mississippi River coming to an end, the guys are each finding themselves in the fight of their lives. Gary and Eddie's battle with a competitor has turned deadly and they're going to settle the score with him once and for all. Pool hustler, Matt Mohlke, has partnered up with an old friend for what he hopes is an epic pay day. And the treasure hunters on the Picket Hastings paddleboat think they've found the big dive spot they've been looking for, but an unexpected visitor may ruin their plans. Life on the river is a war and they're all hoping to come out victorious.